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Developmental Neuroscience:
A Concise Introduction
Susan E. Fahrbach

Book Description | Endorsements
Preface [in PDF format] | Introduction [in PDF format]

TABLE OF CONTENTS:

List of Illustrations xi
Preface xv
Acknowledgments xix
What Are Investigative Reading Questions? xxi
Teaching Using the Primary Literature and Investigative Reading Questions to Complement the Text xxiii

Chapter 1 Introduction

  • What Do We Mean When We Say "Neural Development"? 1
  • What Is in This Book and How to Use It 1
  • Methods for Studying Development of the Nervous System 3
  • Human Brain Imaging 17
  • The Future 19
  • Notes 20
  • Investigative Reading 20

Chapter 2 Overview of Nervous System Development in Humans

  • How Do We Know What We Know? 23
  • Start by Working Backward 24
  • The Carnegie Stages of Embryonic Development 26
  • Development of the Fetal Brain 31
  • Neural Tube Defects 33
  • Notes 34
  • Investigative Reading 35

Chapter 3 Animal Models

  • Model Organisms 37
  • Some Helpful Concepts for Thinking about Animal Models 38
  • Practical Considerations 40
  • The Mouse, Mus musculus 41
  • The Zebrafi sh, Danio rerio 44
  • The Fruit Fly, Drosophila melanogaster 48
  • The Nematode Worm, Caenorhabditis elegans 52
  • Typical Neurons 55
  • Gray Matter and White Matter 57
  • Phylogenetic Relationships 57
  • Notes 60
  • Investigative Reading 61

Chapter 4 Early Events

  • Axis Determination and Neural Induction 63
  • Defining Anterior and Making a Head 63
  • Neural Induction 74
  • Notes 77
  • Investigative Reading 79

Chapter 5 Neurogenesis

  • Production of Neurons by Neural Progenitors 81
  • Neurogenesis in C. elegans 83
  • Neurogenesis in Drosophila 88
  • Neurogenesis in Zebrafi sh 97
  • Neurogenesis in the Mouse 99
  • Neurogenesis in Humans 106
  • Adult Neurogenesis 110
  • Notes 116
  • Investigative Reading 118

Chapter 6 Later Events

  • Not All Animals Are Segmented 121
  • Regionalization in the Drosophila Nervous System 121
  • Regionalization in the Vertebrate Nervous System 128
  • Histogenesis of the Mammalian Cortex 135
  • Notes 140
  • Investigative Reading 141

Chapter 7 Becoming a Neuron

  • Axons, Dendrites, and the Formation of Synapses 143
  • The Decision to Grow a Process 145
  • Microtubules, Actin, and Growth Cones 147
  • Axon Path Finding 152
  • Synaptogenesis 160
  • Notes 164
  • Investigative Reading 166

Chapter 8 Glia

  • Glia and Neurons 169
  • Glia in C. elegans 170
  • Glia in Drosophila 171
  • Glia in Zebrafish 176
  • Glia in Mice 179
  • Glia in Humans 189<
  • Fruit Flies and Glioblastoma 192
  • Notes 194
  • Investigative Reading 195

Chapter 9 Maturation

  • Growing Up 197
  • Metamorphosis 197
  • Adolescence 206
  • Summary 209
  • Notes 210
  • Investigative Reading 211

Chapter 10 Thinking about Intellectual Disability in the Context of Development

  • Neuroscience and Intellectual Disability 213
  • Perturbations of Neuronal Migration 215
  • Dendritic Abnormalities 219
  • Neonatal Hypothyroidism 221
  • Rett Syndrome 222
  • Fragile X Syndrome 225
  • Down Syndrome 228
  • Fetal Alcohol Syndrome 231
  • Nonmammalian Models 234
  • Reality Check 237
  • Notes 238
  • Investigative Reading 239

Abbreviations 241
References 251
Online Resources 271
Full Citations for Investigative Reading Exercises 277
Index 281

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File created: 4/17/2014

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