TABLE OF CONTENTS: Acknowledgments xi Introduction 1 Chapter 1: Differences in Response to Disease 8 Chapter 2: Oxford and the National Institutes of Health: Inherited Variation and Susceptibility to Disease 29 Chapter 3: Polymorphisms and Geography: Disease, Genetics, and Evolutionary Biology 42 Chapter 4: We Discover a New Polymorphism: The Ag System 65 Chapter 5: The Discovery of Australia Antigen 72 Chapter 6: What Is Australia Antigen? 84 Chapter 7: Identifying the Hepatitis B Virus 106 Chapter 8: The Control of Posttransfusion Hepatitis 119 Chapter 9: The Hepatitis B Vaccine 134 Chapter 10: Hepatitis B Virus and Cancer of the Liver 147 Chapter 11: What Is Now Known about HBV? 159 Chapter 12: Back to Polymorphisms and Inherited Susceptibility to Disease 193 Chapter 13: HBV and Its Connections: Current Research and the Future 203 Appendix 1: Scientists and Staff at Fox Chase Cancer Center Referred to in the Text 215 Appendix 2: Research on Hyaluronic Acid 219 Appendix 3: The National Institutes of Health and the Funding of Basic Medical Research 221 Appendix 4: Molecular Biology 223 Appendix 5: A Gazetteer of Selected Place-Names Used in the Text 229 Index 233
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