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Robustness and Evolvability in Living Systems
Andreas Wagner

Book Description | Reviews
Chapter 1 [HTML] or [PDF format]

TABLE OF CONTENTS:

List of Figures ix
Acknowledgments xiii
Chapter 1: Introduction 1

PART I: ROBUSTNESS BELOW THE GENE LEVEL 13

Chapter 2: The Genetic Alphabet 15
Chapter 3: The Genetic Code 25
Chapter 4: RNA Structure 39
Chapter 5: Proteins and Point Mutations 62
Chapter 6: Proteins and Recombination 78

PART II: ROBUSTNESS ABOVE THE GENE LEVEL 91

Chapter 7: Regulatory DNA Regions and Their Reorganization in Evolution 93
Chapter 8: Metabolic Pathways 104
Chapter 9: Metabolic Networks 120
Chapter 10: Drosophila Segmentation and Other Gene Regulatory Networks 143
Chapter 11: Phenotypic Traits, Cryptic Variation, and Human Diseases 161
Chapter 12: The Many Ways of Building the Same Body 175

PART III: COMMON PRINCIPLES 193

Chapter 13: Neutral Spaces 195
Chapter 14: Evolvability and Neutral Mutations 217
Chapter 15: Redundancy of Parts or Distributed Robustness? 228
Chapter 16: Robustness as an Evolved Adaptation to Mutations 247
Chapter 17: Robustness as an Evolved Adaptation to Environmental Change and Noise 270
Chapter 18: Robustness and Fragility: Advantages to Variation and Trade-offs 281

PART IV: ROBUSTNESS BEYOND THE ORGANISM 295

Chapter 19: Robustness in Natural Systems and Self-Organization 297
Chapter 20: Robustness in Man-made Systems 310
Epilogue: Seven Open Questions for Systems Biology 321
Bibliography 323
Index 359

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File created: 7/11/2014

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